Lake Simcoe Regional Airport (IATA: YLK, ICAO: CYLS), formerly the Oro Barrie Orillia Regional Airport, is a registered aerodrome that operates as a regional airport located near Highway 11 in the township of Oro-Medonte, Ontario, Canada. The airport is operated by Lake Simcoe Regional Airport Inc., a municipal service corporation jointly owned by the County of Simcoe (90%) and the City of Barrie (10%).

The airport is classified as an airport of entry by Nav Canada and is staffed by the Canada Border Services Agency (CBSA) on a call-out basis from Billy Bishop Toronto City Airport. CBSA officers at this airport can handle aircraft with no more than 24 passengers. The airport has published instrument approaches.