Columbia Regional Airport (IATA: COU, ICAO: KCOU) is a commercial passenger airport serving Columbia, Missouri. Located about 12 miles (19 km) southeast of Columbia in Boone County, Missouri, it is the only commercial airport in Mid-Missouri and also serves the state capital of Jefferson City. As of 2022, commercial passenger service is provided by American Airlines subsidiary American Eagle. The airport opened in 1968 (1968), replacing the Columbia Municipal Airport off of Interstate 70. It is frequently used for charter flights by college athletic teams visiting the University of Missouri and for MU team flights.

In 2019, airport officials extended the 6,500-foot runway to 7,400 feet and added a new 5,400 foot crosswind runway. On October 26, 2022, the airport opened the airport's 56,000 ft2 terminal with three jetways.

Columbia Regional is included in the Federal Aviation Administration (FAA) National Plan of Integrated Airport Systems for 2021–2025, in which it is categorized as a non-hub primary commercial service facility. Federal Aviation Administration records say the airport had 12,719 passenger boardings (enplanements) in calendar year 2008, 26,842 in 2009 and 38,293 in 2010.

Scheduled passenger service was subsidized by the U.S. Department of Transportation via the Essential Air Service program until 2010, when Pinnacle Airlines dba Delta Connection began providing subsidy-free service.