La Crosse Regional Airport (IATA: LSE, ICAO: KLSE, FAA LID: LSE) is a public airport located 5 nautical miles (9.3 km; 5.8 mi) northwest of La Crosse, a city in La Crosse County, Wisconsin, United States. Until August 2013 the airport was called La Crosse Municipal Airport.

It occupies the northern area of French Island, next to the Mississippi River. La Crosse's airport is the closest scheduled airline airport to the U.S. Army Fort McCoy base near Sparta, Wisconsin.

The Federal Aviation Administration (FAA) National Plan of Integrated Airport Systems for 2023–2027 categorized it as a non-hub primary commercial service facility. It is the sixth busiest of eight commercial airports in Wisconsin in terms of passengers served.