Luke Air Force Base (IATA: LUF, ICAO: KLUF, FAA LID: LUF) is a United States Air Force base in Maricopa County, Arizona, United States. It is located 7 miles (6.1 nmi; 11 km) west of the central business district of Glendale, and 15 miles (13 nmi; 24 km) west of Phoenix.

Luke AFB is a major training base of the Air Education and Training Command (AETC), training pilots in the F-16 Fighting Falcon. On 31 March 2011, the F-35 Lightning II was announced to be replacing the F-16 as the primary training aircraft at Luke, although the date of deployment of the new aircraft to Luke and reorganization plans were not announced. On 16 July 2013, the Air Force announced that Luke AFB will house a total of 144 F-35A Lightning IIs. The first F-35A Lightning II arrived to the base on March 10, 2014.

It is a designated superfund site due to a number of soil and groundwater contaminants.