Tupelo Regional Airport (IATA: TUP, ICAO: KTUP, FAA LID: TUP) is a public use airport located 3.7 miles; 3.2 nautical miles (6 km) west of the central business district of Tupelo, a city in Lee County, Mississippi, United States. It is owned by the Tupelo Airport Authority. The airport is mostly used for general aviation, but is also served by one commercial airline with scheduled passenger service subsidized by the federal Essential Air Service (EAS) program. Many college football teams visiting the University of Mississippi (Ole Miss), 49 miles west in Oxford, fly into Tupelo.

As per the Federal Aviation Administration, this airport had 15,985 passenger boardings (enplanements) in calendar year 2008, 13,319 in 2009, and 12,749 in 2010. The National Plan of Integrated Airport Systems for 2011–2015 categorized it as a primary commercial service airport.