La Isabela International Airport (IATA: JBQ, ICAO: MDJB) opened in 23 February 2006 to replace Herrera International Airport. The first flight to land at the airport was a Caribair flight from Port-au-Prince, Haiti.

It primarily serves the Dominican Republic with domestic flights and international flights to other Caribbean islands. La Isabela Airport is a hub for Dominican airlines that operate small aircraft. The airport has the largest number of hangars in the country (+40) for Dominican-based carriers. It is, as of June 2020, also the only airport in Santo Domingo that serves domestic destinations, as Las Americas International Airport, the Santo Domingo's larger, main airport, lacks domestic air service.