The San Isidro Air Base (Spanish: Base Aérea de San Isidro) (ICAO: MDSI) became operational on March 23, 1953 and is located 25 km east of Santo Domingo. It was named Base Aérea Trujillo until 1961, when the name was changed to San Isidro. Most of the units, aircraft, and helicopters of the Dominican Air Force are based there.

The San Isidro track also has been a venue for automobile racing events.

The Punta Caucedo VOR/DME (Ident: CDO) is located 6.8 nautical miles (12.6 km) west of the airport. The San Isidro VOR/DME (Ident: SIS) is located on the field.