Mezzeh Air Base (Arabic: مطار المزة العسكري; also spelled Mazzeh) was an air base of the former Syrian Air Force located in Mezzeh, Damascus, Syria, south-west of the old centre of Damascus. It had one runway of 8,258 feet (2,517 m) length, at elevation 2,407 feet (734 m). In mid-2013 the airbase was described by the BBC as "an important strategic installation [which] plays a significant role in distributing the government's military supplies." Reuters reported in mid-2013 that it was "used by Syria's elite Republican Guard, Special Forces and Air Force Intelligence, [and] also serves as a private airport for the Assad family." It also said that during the Syrian civil war the base was "used to fire rockets and artillery at rebellious Sunni Muslim neighbourhoods on the edge of the capital." Mezzeh Air Base was also used by the Syrian regime as a jail to imprison opponents during the Syrian civil war. Various inquiries and investigations reported that acts of torture and possible war crimes were committed in the jails of Mezzeh Air Base.

On December 8, 2024, shortly after Damascus fell, it was targeted by Israel airstrikes, most likely to prevent the appropriation of strategic weapons by Syrian rebels, destroying it.