Mariscal Sucre International Airport (IATA: UIO, ICAO: SEQU) was the main international airport that served Quito, Pichincha, Ecuador. It was the busiest airport in Ecuador by passenger traffic, by aircraft movement and by cargo movement, and one of the busiest airports in South America. It was named after Venezuelan-born Antonio José de Sucre, a hero of Ecuadorian and Latin American independence. It began operations on August 5, 1960, and during its last years of operation, handled about 6.2 million passengers and 164,000 metric tons of freight per year. The airport, one of the highest in the world (at 2,800 metres or 9,200 feet AMSL) was located in the northern part of the city, in the Chaupicruz parish, within five minutes of Quito's financial center; the terminals were located at the intersection of Amazonas and La Prensa avenues. Mariscal Sucre International was the largest hub for TAME with an average of 50 daily departures.

The old Mariscal Sucre International Airport ceased all operations at 19:00 on February 19, 2013, following the departure of TAME flight 321 to Guayaquil (scheduled for 18:55). Iberia operated the final international departure from the airport. On the morning of February 20, 2013, all operations moved to the new airport of the same name. The first domestic flights scheduled to arrive at the new airport were TAME Flight 302 originating in Guayaquil, and LAN Flight 2590 originating in Lima, Peru.