Nepean Hospital is a 520-bed teaching hospital. providing tertiary referral services for the Nepean Blue Mountains Local Health District. Nepean Hospital is located at the base of the Blue Mountains in Kingswood, New South Wales, Australia.

The first Penrith hospital was opened in 1860, containing 6 beds and was located on the modern day Cox Street.

Nepean Emergency Department treats over 62,000 admitted patients annually. Opened in Feb 2023 The new Emergency Department is a purpose built facility with an adjacent short stay unit, and provides emergency care for a diverse case mix including paediatric patients. It is supported by multi-speciality services including 24 beds in the Intensive Care Unit, 24-hour interventional cardiology, hematology, neurosurgery, thoracic surgery, urology, plastic surgery, paediatrics and obstetrics and gynaecology.

Also on the Nepean Hospital campus are a Neonatal ICU, Tresillian Family Care Centre, Menopause Service, Nepean Cancer Care Centre, Diabetes Service, in-patient psychiatric unit, Rehabilitation medicine and the Wentworth Centre for Drug and Alcohol Medicine. Nepean hospital hosts 19 operating theatres, with 6 operating theatres which opened in March 2012 & 15 more which opened in 2022. The original operating theatres 1-8 are currently being demolished to build pharmacy services.